Alzheimer’s Treatment via Aspirin

A new path for diminishing Alzheimer's disease pathology is the low-dose aspirin administration, according to new study in a mouse model of the disease published in JNeurosci. The study spots a new role for one of the most extensively used medications in the world.

The impaired clearance of toxic amyloid beta, especially from the hippocampus, is leading mechanism of Alzheimer’s disease, even though the imposed cause of Alzheimer's disease evolution is still hidden. The activation of the cellular machinery is proved to be a promising strategy for slowing the disease because it is responsible for removing waste from the brain.

Building on studies demonstrating a link between aspirin and reduced risk and prevalence of Alzheimer's disease, Kalipada Pahan and colleagues show that this common over-the-counter medication decreases amyloid plaque pathology in mice by stimulating lysosomes -- the component of animal cells that help clear cellular debris. The research adds to aspirin's established uses for pain relief and for the treatment of cardiovascular diseases.

Discuss more at:

European Pathology and Infectious Disease Conference

Helsinki, Finland

November 26-27, 2018

https://biopathology.pathologyconferences.com/